Jan Neumann

Hahn-Meitner-Weg 1, B.2.17
55128 Mainz
Telefon: +49(6131)305-7702

PhD student at Max Planck Institute for Chemistry, Mainz, Germany. 2014-present

Physics (M.Sc.), University of Heidelberg

Chronic inflammatory processes play an important role in different diseases. Pattern recognition receptors (PRR) are involved in the detection of invading pathogens. Activation of these receptors leads to the induction of different downstream signaling pathways and therefore to the initialization of the inflammatory response. Our research focus lies mainly on the Toll-like receptor 4 (TLR4) and its downstream signaling molecules like MyD88 and NF-κB.

The goal of this research project is to localize these inflammatory molecules by using single molecule localization microscopy (SMLM). SMLM is one method that had been developed in the last decade to overcome the resolution limit of conventional fluorescence microscopy. Therefore this work is in close cooperation with the Superresolution Microscopy Group by Prof. Cremer at the Institute of Molecular Biology (IMB).