Laboratory of Inflammation & Microscopy - LIM

In the joint Laboratory of Inflammation & Microscopy (LIM), the Max-Planck-Institute for Chemistry (MPIC) and the Institute of Molecular Biology (IMB) in Mainz conduct collaborative research on the molecular processes of inflammation. The research is focusing on the molecular and cellular structures and reaction pathways involved on innate immune reaction pathways and related molecular and cellular structures. Fluorescence microscopy and super-resolution microscopy methods are developed and applied to visualize and quantify molecular aggregations and structural changes in cells during inflammation. The investigations addressing chemical and biological aspects of inflammation build on synergies of the scientific competences of MPIC and IMB.

Current Research Topics and Activities:

  • Subcellular localization of Pattern Recognition Receptors (PRR)
  • Translocation of transcription factors due to PRR-activation
  • Dynamics of the development of Reactive Oxygen Species (ROS)
  • Changes in the chromatin structure during the inflammatory process
  • Mathematic modeling of amplification during inflammatory processes
  • Improvement of super-resolution microscopy data analysis

Coordinators: 
Ulrich Pöschl & Kurt Lucas, Multiphase Chemistry Department, Max Planck Institute for Chemistry (MPIC), Mainz
Christoph Cremer & Udo Birk, Institute of Molecular Biology (IMB), Mainz